The book "Daisy-Head Mayzie" is about a 12-year-old girl named Mayzie who, one day, finds herself with a daisy growing out of her head. This alarms her classroom, family and town, and she even ends up becoming a celebrity. However, that doesn't make her happy. Away from home, towards the end of the book, she is convinced that nobody loves her. It's at this point that The Cat in the Hat, a character from another Dr. Seuss story by the same name, convinces her to try the "he loves me, he loves me not" game on her own daisy. The result is that they love her, so Mayzie is reassured and happily decides to go back home.
- Daisy-Head Mayzie's most noticeable characteristic is the daisy growing out of her head. When Care is first seen, she is found in the Flower Shack basement crying in front of a stalk: the stalk belongs to the daisy visible from the upper section of the shalk. The flower isn't actually growing out of her head, but Care's position seems to make it so it looks like it.
- The Good Grief And Alas hallway references a direct quote from the book: this is what Miss Sneetcher from the book Daisy-Head Mayzie tells the children in order to persuade them to stop mocking Mayzie and making noise, and is also what caused many people to find the connection with the book in the first place.
- Care's final and current form is referred to as "NLM", both in the note and in the pets menu. The note in Care's room in the Child Library implies that it stands for "Nobody loves me". This sentence is repeatedly said by Mayzie towards the end of the book.
- Every time a petal is plucked from the daisy, a sound effect is played: for every petal corresponding to an odd number, it's slighlty high-pitched; for every petal corresponding to a even number, it's slightly low-pitched. Additionally, together with the low-pitched sound effect, the screen is dyed with a shade of red; whereas, together with the high-pitched sound effect, it goes back to normal (it's red at the start). This seems to imply that every petal being plucked from the daisy corresponds to either a good or a bad thing depending on its number. This could be a reference to the "he loves me, he loves me not" game that children use to play with daisies. Mayzie plays that same game at the end of the book, with the final result being "he loves me", which is what makes her feel confident that people actually care about her. However, since the number of the petals of the giant daisy in the Flower Shack is 16, an even number, the final result for Care is "he loves me not", which is what may have caused her to glitch out in pain. The connection with the game is further reinforced by the fact that Paul has to set the treadmill in the alternate Even Care to -1 in order to catch her, and that the game refers to this act as a "lie to her": considering that the treadmill seems to be linked to the giant daisy and the number of petals on it, in the context of the "he loves me, he loves me not" game, that would mean that Paul told her she is loved despite the fact that she isn't, just to reassure her.